Table 1.
Characteristics of HIV-1-infected infants (n=10)
Characteristic | Case | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | |
Age at first positive HIV-1 diagnostic test, d |
3 | 3 | 4 | 7 | 3 | 161 | 69 | 49 | 39 | 87 |
HIV-1 diagnostic test results a | 3 (positive) |
3 (3 760 000) |
4 (760) | 7 (1183) | 3 (2922) | 4 (<400) | 4 (<400) | 4 (<400) | 39 (466 000) |
87 (750 000) |
38 (positive) |
52 (14 500) |
60 (>750 00 0) |
54 (650 998) |
46 (382 916) |
161 (314 760) |
69 (602 555) |
49 (580 000) |
242 (720 000) |
213 (395 712) |
|
79 (positive) |
69 (597 242) |
74 (1 571 690) |
187 (710 104) |
188 (123 694) |
59 (123 089) |
Not tested |
Not tested |
|||
Estimated timing of MTCT of HIV-1 |
In utero | In utero | In utero | In utero | In utero | Intrapartum | Intrapartu m |
Intrapartu m or postnatal |
Unknown | Unknown |
Birth weight, g | 2600 | 2400 | 3100 | 2900 | 3000 | 2900 | 3500 | 3200 | 2900 | 3800 |
Pediatric estimate of gestational age at delivery, wk |
36 | 38 | 39 | 39 | 41 | 38 | 38 | 38 | 38 | 40 |
Antiretroviral prophylaxis regimen |
Zidovudin e |
Zidovudi ne + lamivudin e + lopinavir/ ritonavir |
Zidovudi ne |
Zidovudin e |
Zidovudi ne |
Zidovudine | Zidovudin e |
Zidovudin e |
Zidovudi ne |
Zidovudi ne |
Exposure to breast milk | No | No | No | No | No | No | No | Yes b | No | No |
Resistance testing: | ||||||||||
Study visit | Enrollme nt |
Data not available |
6–12 wk | 6–12 wk | 6–12 wk | Data not available | 6–12 wk | 6–12 wk | 6–12 wk | 6 mo |
HIV-1 subtype | B | --- | B | F1 | B | --- | B | B | C | B |
Drug resistance | None | --- | None | None | None | --- | None | None | None | Efavirenz ; nevirapin e |
Abbreviation: MTCT, mother-to-child transmission.
Values are given as age in days at HIV-1 testing (test result). HIV-1 diagnostic test results refer to DNA polymerase chain reaction assay (positive or negative) and viral load (copies/mL).
Case 8 was exposed to breast milk on 1 occasion at approximately 2 weeks of age.