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. Author manuscript; available in PMC: 2016 May 24.
Published in final edited form as: Curr Top Membr. 2013;72:313–346. doi: 10.1016/B978-0-12-417027-8.00009-X

Figure 1.

Figure 1

Components of the immunological synapse. The mature immunological synapse is composed of three SMACs and at least two types of microclusters (MC). The dSMAC (outer yellow) is f-actin rich and is the location in which TCR (green) and LFA-1 (red) microclusters form. The pSMAC is a perforated network of engaged LFA-1 (red) that contains some TCR microclusters in the perforations. The outer cSMAC (pale green) contains a small amount of TCR and accumulated all the CD28 (over time). It is active in signaling. The inner cSMAC (green) is dependent upon ubiquitin recognition and is not active in signaling. There is inward movement of MCs, inward movement of LFA-1 in the pSMAC (unpublished observations) and there is inward movement of TCR from the outer to the inner cSMAC.