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. 2016 Apr 15;5:e14211. doi: 10.7554/eLife.14211

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© 2016, Wang et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 9. — (A) Binding of Syt1 C2B to PI(4,5)P2 and primed trans-SNARE complex on the plasma membrane before Ca²⁺ influx. (B) The simultaneous interactions of C2B with primed trans-SNARE complex and PI(4,5)P2-PS-containing membranes in response to Ca²⁺ cause bucking toward the synaptic vesicle of the plasma membrane. Note that a similar model has been recently proposed (Zhou et al., 2015). (C) Membrane bucking might cooperate with the action of Syt1 C2B in displacing inhibitory complexin-1 to facilitate the continuous helical SNARE complex assembly, thus triggering membrane fusion and neurotransmitter release. SV, synaptic vesicle; PM, pre-synaptic membrane.

DOI: http://dx.doi.org/10.7554/eLife.14211.017