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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Epilepsy Res. 2015 May 19;115:8–16. doi: 10.1016/j.eplepsyres.2015.05.006

Figure 3.

Figure 3

Effect of lacosamide on interictal spikes associated ripples—A. Example of a ripple associated with an interictal spike in a control animal. B. Bar graph showing the average rates of ripples associated with interictal spikes in all regions. Rates of ripples associated with interictal spikes were significantly lower in CA3 and in the subiculum of LCM-treated animals compared to controls. C. Average rates of ripples associated with interictal spikes from day 4 to day 14 after SE in controls and LCM-treated animals, in CA3 and subiculum (* p < 0.05, ** p < 0.01) (vertical dotted lines define the averaged peak of seizure occurrence in control animals, around day 9 after SE).