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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Seizure. 2015 Jul 10;31:33–40. doi: 10.1016/j.seizure.2015.07.002

Fig. 3.

Fig. 3

Ictal synchronization between structures. Synchronicity between the entorhinal cortex and subiculum can be manipulated by severing connections between the regions. (A) Traces of a sudden onset ictal event during control (4AP only) conditions and after cutting the connections between the subiculum and entorhinal cortex. (B) Traces depicting the change in synchronization between the entorhinal cortex and subiculum in a slice characterized by LVF ictal events. In both panels A and B, the dotted line highlights the trains of positive-going spikes that occur in the subiculum after the cut. (C) Schematic showing the location of the “cut” and the electrode placement. (D) Bar graphs indicating the change in duration of ictal events following the cut in slices characterized by either sudden or LVF onset patterns. (E) Bar graphs showing the change in interval between either sudden onset or LVF ictal events following the cut (*P < 0.05).