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. Author manuscript; available in PMC: 2016 May 24.
Published in final edited form as: Epilepsia. 2012 Nov 28;54(4):596–604. doi: 10.1111/epi.12041

Figure 2.

Figure 2

Interictal activity induced by systemic 4AP administration. (A) EEG recordings obtained from an animal before and after the systemic administration of 4AP (arrow); note the early appearance of interictal spikes in the subiculum (asterisks) that precede the occurrence of the first seizure 12 min after injection. (B) EEG recordings from a different rat after the administration of 4AP demonstrate at low speed the occurrence of interictal spikes only in the subiculum before the occurrence of the first seizure. Insets show simultaneous recordings (4 s) in all regions during an interictal spike occurring in the subiculum (asterisk). (C) Representative recordings showing interictal spikes occurring in all regions once seizures started to occur. These interictal spikes had no fixed site of origin.