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. Author manuscript; available in PMC: 2016 May 24.
Published in final edited form as: Neurobiol Dis. 2014 Mar 28;67:97–106. doi: 10.1016/j.nbd.2014.03.012

Fig. 5.

Fig. 5

HFOs co-occurring with type 1 and type 2 spikes as well as outside of them. A. Example of a ripple co-occurring with a type 1 spike in the CA3 region of a pilocarpine-treated rat one day before the occurrence of the first spontaneous seizure. B. Example of a fast ripple co-occurring with a type 2 spike in the CA3 region of the same animal one day after the occurrence of the first seizure. C. Example of a fast ripple occurring in EC outside of interictal spikes on the day of the occurrence of the first seizure. HFOs in A, B and C are highlighted in red. D. Bar graph showing the average duration of ripples and fast ripples co-occurring with spikes and outside of spikes in CA3 and EC. Note that fast ripples occurring outside of spikes were significantly shorter in duration in EC (*p < 0.05).