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. Author manuscript; available in PMC: 2016 May 24.
Published in final edited form as: CNS Drugs. 2009;23(7):555–568. doi: 10.2165/00023210-200923070-00002

Fig. 1.

Fig. 1

Intracellular (top trace) and field (bottom trace) recordings from rat brain slices from the entorhinal cortex (a) and cingulate cortex (b) during application of fampridine (4-aminopyridine) 50 μmol/L. Ictal network discharges (on the right side of the trace) correspond to high frequency sodium-dependent action potentials that ride on network-driven depolarizations, while interictal events (on the left side of the trace) are associated with single action potentials or bursts of action potentials. Insets on the right are time expansions of the onset of ictal discharges and clearly show the very high frequency (up to 200 Hz) discharges of action potentials (panel [a] modified from Lopantsev and Avoli,[4] with permission).