Table I.
Sodium current parameter | Antiepileptic drugs
|
References | |||
---|---|---|---|---|---|
CBZ | LTG | PHT | LCM | ||
Reduction in the peak current | +++ | ++ | ++ | ++ | 27–29 |
Depolarizing shift of V50 a activation | − | − | −b | − | 30–33 |
Hyperpolarizing shift of V50a fast inactivation | ++++ | +++ | + | − | 28,33 |
Hyperpolarizing shift of V50a slow inactivation | ++ | +++ | +++ | ++++ | 27,33 |
10 Hz frequency- dependent facilitation of block | + | + | + | − | 27,33 |
Slowed recovery time from fast inactivation | ++ | ++ | ++ | − | 27,33 |
Slowed recovery time from slow inactivation | − | NR | NR | − | 33 |
V50 indicates the membrane potential where 50% of the processes described (activation and fast or slow inactivation, respectively) are operating.
Effect with PHT 10 μmol/L.
NR = not reported; − indicates no effect (0–10% change; <3 mV); + indicates small effect (10–35% change; 3–7 mV); ++ indicates moderate effect (35–60% change; 8–11 mV); +++ indicates large effect (60–85% change; 12–16 mV): ++++ indicates almost complete effect (>85% change; >17 mV).