Fig. 3.
A Effects induced by baclofen (0.5 μM) on the pharmacologically isolated IPSPs recorded intracellularly with K-acetate+QX314 filled electrodes from NEC and WAG/Rij neurons following single-shock stimuli. Note that the effects exerted in the WAG/Rij cell are less pronounced than in NEC and that these effects are reversed by application of the GABAB receptor antagonist CGP 55845; note also that the stimulus-induced event generated by the WAG/Rij neuron is abolished by bath application of picrotoxin. B Percentage of reduction induced by 0.5. and 5 μM of baclofen on the peak amplitude of the stimulus-induced responses measured in the two types of tissue. Note that values of reduction are significantly (## p < 0.01) different in NEC and WAG/Rij rats at both baclofen doses. ** p < 0.01 vs. baclofen 0.5 μM, Fisher’s LSD test for multiple comparisons.