Table 2.
Predictors of Type 1 Diabetes After Seroconversion in Children With Multiple Islet Autoantibodies
| Variable | 10-Year Risk, % (95% CI) |
Bivariable Hazard Ratio (95% CI) |
P Value |
Multivariable Hazard Ratio (95% CI)a |
P Value |
|---|---|---|---|---|---|
| Serocoversion age, y | |||||
| <3 | 74.9 (69.7-80.1) | 1.72 (1.36-2.17) | <.001 | 1.65 (1.30-2.09) | <.001 |
|
|
|
||||
| ≥3 | 60.9 (51.5-70.3) | 1 [Reference] | 1 [Reference] | ||
|
| |||||
| HLA genotype | |||||
| DR3/DR4-DQ8 | 76.6 (69.2-84.0) | 1.40 (1.12-1.73) | .003 | 1.35 (1.09-1.68) | .007 |
|
|
|
||||
| Other | 66.2 (60.2-72.2) | 1 [Reference] | 1 [Reference] | ||
|
| |||||
| Sex | |||||
| Girls | 74.8 (68.0-81.6) | 1.30 (1.05-1.60) | .02 | 1.28 (1.04-1.58) | .02 |
|
|
|
||||
| Boys | 65.7(59.3-72.1) | 1 [Reference] | 1 [Reference] | ||
|
| |||||
| No. of autoantibodies | |||||
| 3 | 72.1 (66.5-77.7) | 1.27 (1.02-1.59) | .04 | 1.19 (0.95-1.49) | .14 |
|
|
|
||||
| 2 | 65.1 (56.3-73.9) | 1 [Reference] | 1 [Reference] | ||
a
Multivariable hazard ratio includes all listed variables (seroconversion age, human leukocyte antigen genotype, sex, number of autoantibodies).