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. Author manuscript; available in PMC: 2016 May 24.
Published in final edited form as: Nat Chem. 2015 Jun 22;7(8):641–645. doi: 10.1038/nchem.2281

Figure 1. Structure and previous syntheses of paracaseolide A.

Figure 1

In several previous studies (refs 3, 7–10) concomitant thermal dimerization and dehydration of the monomeric alkenylbutenolide 3a was used as the key step. This cycloaddition has been presumed to proceed through the intermediacy of the endo-Diels–Alder adduct 2.