Table 1.

Descriptions of studies included in meta-analysis of Late vs. Early-Onset SLE

Author and Publication Year	Setting (I)npatient (O)utpatient (P)opulation	Study type	Years	Early - onset SLE (n)	Late - onset SLE (n)	Late - onset Age Def.	Newcastle Ottawa Score
Alonso 201219	Spain; I	cohort	1987–2006	91	59	≥50*	6
Antolin 19958	Spain; I	cohort	1980–1992	134	29	>50	7
Appenzeller 200820	Brazil; I	c-c	1974–2005	60	16	≥50*	7
Boddaert 20041	France; O	cohort	1980–2000	114	47	≥50*	6
Cartella 201321	Italy; O	cohort	1976–2008	495	40	≥50	6
Cervera 19939	Europe; P	cohort	1980–1990	910	90	>50*	6
Chen 200922	Taiwan; I/O	cohort	1998–2008	50	19	≥60*	6
Cooper 200223	USA; P	c-c	1997–1999	195	61	≥50	6
Costallat 199413	Brazil; O	cohort	1973–1992	223	10	≥50*	6
Dimant 19792	USA: I/O	cohort	1966–1976	218	16	>50*	6
Domenech 199210	England; I/O	cohort	1985–1991	232	15	≥50*	6
Feng 201024	China; I	cohort	unknown	1550	131	≥50*	5
Font 19913	Spain; I/O	cohort	1980–1988	210	40	≥50*	6
Gomez 200625	Spain; P	cohort	1992-?	259	91	≥50*	6
Hashimoto 19874	Japan; O	cohort	1955–1985	501	21	≥50*	6
Ho 199811	China; O	cohort	1971–1997	100	25	>50*	7
Jacobsen 199814	Denmark; P	cohort	1975–1995	354	103	≥50	6
Janwityanujit 199512	Thailand; I	cohort	1990–1992	308	27	≥50*	7
Karoubi Nordon 20075	France; O	c-c	1995–2003	11	11	≥50	8
Lalani 201026	Canada; P	cohort	2005-?	1367	161	≥50*	6
Liu 198827	Taiwan; I/O	cohort	1977–1986	207	11	≥50*	7
Maddison 198728	England; O	cohort	unknown	93	19	>60*	6
Mak 199829	China; I	cohort	1985–1995	89	13	>50*	6
Mok 200530	China; I/O	cohort	1991–2003	213	22	>50*	8
Pu 200031	Taiwan; I	cohort	1988–1998	152	42	≥50	6
Sayarlioglu 200432	Turkey; O	cohort	1978–2001	100	20	≥50*	6
Shaikh 19956	Malaysia; O	cohort	1976–1992	52	17	>50	6
Stefanidou 201333	Greece; P	cohort	1989–2007	430	121	≥50*	6
Tang 201134	China; O	cohort	1986–2008	100	35	≥50	6
Tomic-Lucic 201335	Serbia; O	c-c	unknown	30	30	≥50	7
Voulgari 200236	Greece; O	cohort	1981–2000	398	90	≥55*	7
Wang 20077	China; I/O	cohort	1999–2005	615	80	≥50*	6
Webb 201137	USA; P	cohort	unknown	1038	168	≥50	5
Wilson 198138	USA; O	cohort	1970–1978	49	17	≥50*	7
Xu 201139	China; I	cohort	2000–2008	241	30	≥50	6
TOTAL				11189	1727

Abbreviations: c-c=case control;

^*indicates SLE patients < 18 years old included in analysis.