Table 2.
Meta-analysis summary statistics for cutaneous manifestations in Late vs Early-onset SLE
| Cutaneous Manifestation |
Total Cases n= 12,916 |
Late- onset n= 1,727 |
Early- onset n= 11,189 |
OR (95% CI) |
Heterogeneity I2 (%), p |
|---|---|---|---|---|---|
| Malar rash | 12,731 | 1,691 | 11,040 |
0.43 (0.35,0.52) |
64, <0.001 |
| Mucosal ulcerations | 11,697 | 1,616 | 10,081 | 0.88 (0.74, 1.04) |
22, 0.14 |
| Discoid | 10,997 | 1,520 | 9,477 | 1.11 (0.91, 1.34) |
9, 0.33 |
| Photosensitivity | 12,318 | 1,698 | 10,620 |
0.72 (0.59, 0.88) |
54, <0.001 |
| Sicca | 5,489 | 833 | 4,656 |
2.45 (1.91, 3.14) |
13, 0.31 |
| Raynaud | 8,515 | 1,194 | 7,321 |
0.84 (0.71, 0.99) |
14, 0.26 |
| Alopecia | 7,290 | 992 | 6,298 |
0.63 (0.48, 0.82) |
36, 0.06 |
| Cutaneous vasculitis | 3,711 | 480 | 3,231 | 0.78 (0.49, 1.26) |
37, 0.11 |
| Livedo reticularis | 1,619 | 197 | 1,422 | 0.63 (0.17, 2.31) |
62, 0.03 |
| Subacute cutaneous lupus | 1,060 | 120 | 940 | 0.92 (0.43, 1.98) |
0, 0.80 |
I2 interpretation: low heterogeneity ≤25%, moderate 50%, and high >75%