Table 1.

Examples of drugs targeting the lysosome in cancer

Target	Compound	Mode of action	Clinical potential	Reference
End stage of autophagy	HCQ	Autophagolysosome formation	Autophagy inhibition	42, 55
	Lyso 5	Autophagolysosome formation	Autophagy inhibition	57
Vacuolar H+-ATPase	Bafilomycin A1	Deacidification	H+-ATPase inhibition	62
	Archazolid	Deacidification	H+-ATPase inhibition	64
	Cleistanthin A	Deacidification	H+-ATPase inhibition	65
	Manzamine A	Deacidification	H+-ATPase inhibition	66
ASM	Cationic amphiphilic drugs	Modulate ASM metabolism	ASM modulator	77
Lysosomal hydrolases	Pepstatin	Inhibition of cathepsin D	Acid protease inhibitor	68
	CA-074	Inhibition of cathepsin B	Acid protease inhibitor	69
	Z-FF-FMK	Inhibition of cathepsin L	Acid protease inhibitor	72
	Cat S/6n	Inhibition of cathepsin S	Acid protease inhibitor	71
HPS70	PES	ASM metabolism, LMP	ASM modulator	76