Table 2. Top 20 regions of association for endophenotype and SNP markers, chromosome position, allele and frequency, closest gene, P-values with and without FDR correction.
| Endophenotype | Marker | Chromosome | Position | Allele (Frequency) | Closest gene(s) | P-value |
|
|---|---|---|---|---|---|---|---|
| Raw | FDR-corrected | ||||||
| ROCFT | rs6551660 | 4 | 62708149 | G (0.43) | LPHN3 | 0.0009 | 0.0260 |
| rs2013374 | 4 | 62697759 | G (0.37) | LPHN3 | 0.0014 | 0.0260 | |
| rs2122642 | 4 | 62698263 | C (0.37) | LPHN3 | 0.0016 | 0.0260 | |
| rs2345041 | 4 | 62698356 | C (0.37) | LPHN3 | 0.0016 | 0.0260 | |
| WISC block design | rs2228130 | 17 | 7404990 | A (0.03) | POLR2A | 0.0018 | 0.0260 |
| ROCFT | rs4484334 | 4 | 62499840 | T (0.49) | LPHN3 | 0.0024 | 0.0260 |
| rs1510921 | 4 | 62895591 | T (0.19) | LPHN3 | 0.0026 | 0.0260 | |
| rs7695134 | 4 | 62704851 | T (0.42) | LPHN3 | 0.0027 | 0.0260 | |
| rs2282794 | 5 | 141981708 | A (0.11) | FGF1 | 0.0037 | 0.0317 | |
| WISC FSIQ | rs2236196 | 20 | 61977555 | G (0.26) | CHRNA4 | 0.0043 | 0.0331 |
| WISC block design | rs333117 | 17 | 4395169 | C (0.45) | SPNS3/SPNS2 | 0.0051 | 0.0350 |
| WISC PIQ | rs2236196 | 20 | 61977555 | G (0.26) | CHRNA4 | 0.0061 | 0.0331 |
| ROCFT | rs10001410 | 4 | 62474228 | C (0.48) | LPHN3 | 0.0062 | 0.0350 |
| rs1948616 | 4 | 62487687 | T (0.48) | LPHN3 | 0.0067 | 0.0350 | |
| WISC PIQ | rs1565902 | 4 | 62408619 | C (0.37) | LPHN3 | 0.0069 | 0.0350 |
| rs6551678 | 4 | 63023050 | G (0.31) | LOC391656/LOC100131441 | 0.0082 | 0.0350 | |
| WISC FSIQ | rs3746372 | 20 | 62032034 | G (0.27) | LOC100130152/KCNQ2 | 0.0083 | 0.0350 |
| ROCFT | rs990640 | 4 | 62698936 | T (0.37) | LPHN3 | 0.0083 | 0.0350 |
| ACVT-O | rs1982177 | 17 | 4119993 | C (0.45) | ANKFY1 | 0.0091 | 0.0350 |
| ACVTCR | rs1982177 | 17 | 4119993 | C (0.45) | ANKFY1 | 0.0091 | 0.0350 |
Abbreviations: ACVT, ‘A'-cancelation and vigilance test; FDR, false discovery rate; FSIQ, full scale intelligence quotient; PIQ, performance intelligence quotient; ROCFT, Rey-Osterrieth complex figure test; SNP, single nucleotide polymorphism; WISC, Wechsler Intelligence Scale for Children.