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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Addict Biol. 2015 Nov 24;22(2):303–317. doi: 10.1111/adb.12323

Figure 1. Blockade of Ox1Rs does not significantly alter FR1 responding for remifentanil.

Figure 1

A) Acquisition of remifentanil self-administration (n = 24). B) Rats quickly learned to discriminate between the lever that delivers drug (the active lever) and the inactive lever. C-G) After stabilizing on the FR1 self-administration procedure, subjects were pretreated with 30 mg/kg of the OxR1 antagonist SB-334867 or vehicle prior to an FR1 session (n = 16, within-subjects design). SB did not affect the number of infusions earned (C) or the number of active (D) or inactive (E) lever presses. Time course analyses revealed no effect of SB on the cumulative number of infusions throughout the session (F); however, there was a modest effect of SB on cumulative active lever presses (G). n.s. = not statistically different; *p < 0.05; p < 0.001.