Table 4. Associations between the PRS for neuroticism based on the UK Biobank Neuroticism GWAS summary results, and neuroticism in GS:SFHS and QIMR samples, controlling for age, sex and 10 genetic principal components for population structure.
| Threshold | β | s.e. | Percentage variance explained | P-value | Number of SNPs |
|---|---|---|---|---|---|
| GS:SFHS sample, N=7196 | |||||
| PRS<0.01 | 0.107 | 0.016 | 0.59 | 4.58 × 10−11 | 4531 |
| PRS<0.05 | 0.123 | 0.014 | 1.00 | 5.27 × 10−19 | 15 533 |
| PRS<0.1 | 0.131 | 0.013 | 1.30 | 3.23 × 10−23 | 27 216 |
| PRS<0.5 | 0.132 | 0.012 | 1.48 | 3.45 × 10−26 | 95 552 |
| PRS<1 | 0.131 | 0.012 | 1.46 | 6.93 × 10−26 | 146 088 |
| QIMR sample, N=8687 | |||||
| PRS<0.01 | 0.070 | 0.012 | 0.49 | 8.5 × 10−09 | 12 146 |
| PRS<0.05 | 0.081 | 0.012 | 0.66 | 5.3 × 10−12 | 41 006 |
| PRS<0.1 | 0.086 | 0.012 | 0.74 | 1.5 × 10−13 | 68,979 |
| PRS<0.5 | 0.086 | 0.012 | 0.75 | 7.7 × 10−14 | 204 632 |
| PRS<1 | 0.088 | 0.011 | 0.77 | 3.2 × 10−14 | 280 716 |
Abbreviations: GS:SFHS, Generation Scotland: Scottish Family Health Study; GWAS, genome-wide association study; PRS, polygenic risk scores; QIMR, Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute; SNP, single-nucleotide polymorphism.