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. 2016 May 25;36(21):5808–5819. doi: 10.1523/JNEUROSCI.3857-15.2016

Figure 8.

Figure 8.

PBA improved cone visual function in KI mice but not in rd12 mice. A, Representative photopic ERG in 10-week-old WT and KI mice treated with PBA or saline for 8 weeks. ERG responses were elicited with the indicated flash intensities of white light under a rod-saturating background light. B, Amplitudes of photopic ERG b-waves, evoked with the indicated achromatic light flashes, in WT and KI mice treated with PBA or saline. C, Representative ERG responses of S-cones in 10-week-old WT, KI, and rd12 mice treated with PBA or saline for 8 weeks. Data were acquired using the indicated flash intensities of 360 nm UV light under a rod-saturating background light. D, Amplitudes of S-cone b-waves, evoked with the indicated UV light flashes, in KI and rd12 mice treated with PBA or saline. Asterisks indicate statistically significant differences between PBA- and saline-treated KI mice (p < 0.01). Note the similar b-wave amplitudes in PBA- and saline-treated rd12 mice. Error bars indicate SD (n = 7).