Table 2.
Whole-brain correlates of intensity versus pleasantness contrasts
| Hemisphere | Peak x, y, z | Peak Z | No. of voxels | p-value | |
|---|---|---|---|---|---|
| Intensity > pleasantness | |||||
| Primary somatosensory cortex | R | 28, −22, 62 | 5.78 | 1158 | p < 0.00001 |
| Secondary somatosensory cortex/posterior insula | R | 50, 50, −24 | 4.99 | 379 | p < 0.0001 |
| Secondary somatosensory cortex | L | −62, −18, 10 | 4.69 | 360 | p < 0.0001 |
| Pleasantness > intensity | |||||
| Bilateral frontal cortex | L | −10, 38, 0 | 5.92 | 9347 | p < 0.00001 |
| White matter | L | −36, −24, 44 | 4.41 | 594 | p < 0.00001 |
| Cerebellum | R | 20, −46, −36 | 4.66 | 526 | p < 0.00001 |
| White matter | L | −24, −30, −16 | 4.50 | 363 | p < 0.0001 |
| Cerebellum | L | −12, −46, −34 | 4.59 | 272 | p = 0.0003 |
| Superior frontal gyrus | L | −18, −6, 70 | 4.24 | 170 | p = 0.006 |
Clusters above a threshold of Z > 3 are displayed with whole-brain correction for multiple comparisons (p < 0.01; n = 26). x, y, and z refer to the MNI coordinates corresponding to the left–right, anterior–posterior, and inferior–superior axes, respectively; Z refers to the highest Z-score within a cluster. A positive Z-value indicates a positive correlation between the subject's ratings and the BOLD response.