Table 1. In cases where identical epitopes are targeted by multiple individuals, escape occurs more rapidly when the fitness cost of escape is lower.

Epitope	Patient	HLA restriction	Fitness cost ΔE	Escape time (days)
TPQDLNTML (TL9)	CH185	B*81:01	4.3	122
	CH159	B*81:01	6.1	>1,103*
TSTLQEQVAW (TW10)	CAP239	B*58:01	−1.4	1
	CH198	B*57:03	0.1	220
WHLGHGVSI (WI9)	CAP210	B*15:10	2.8	127
	CAP45	B*15:10	4.7	408†
EEVGFPVRPQV (EV11)	CH164	B*45:01	2.6	31
	CAP45	B*45:01	4.0	43

^*No escape observed (final sequencing time).

^†Antigen-processing escape.