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. 2016 May 23;54(6):1586–1592. doi: 10.1128/JCM.00298-16

TABLE 3.

Comparison of ranges, MIC50s, MIC90s, and percentage of isolates susceptible/intermediate to imipenem, meropenem, and ertapenem for Nocardia isolates by broth microdilution

Complex or species and drug Intermediate breakpoint (μg/ml) No. of isolates tested MIC (μg/ml)
% susceptible/intermediate
Range 50% 90%
N. cyriacigeorgica
    Imipenem 8 25 ≤1–32 8 >16 60
    Meropenem 8 25 4–>16 8 >16 68
    Ertapenem 4a 26 2–>16 8 >16 15
N. nova complex
    Imipenem 8 57 ≤0.5–8 ≤1 2 100
    Meropenem 8 54 ≤0.5–16 ≤1 4 94
    Ertapenem 4a 57 0.5–16 2 4 96
N. abscessus
    Imipenem 8 13 2–32 >16 32 23
    Meropenem 8 11 1–8 2 4 100
    Ertapenem 4a 13 0.5–4 2 4 100
N. brasiliensis
    Imipenem 8 23 16–>32 >16 >32 0
    Meropenem 8 23 4–>16 >16 >16 48
    Ertapenem 4a 23 4–>16 >16 >16 26
N. farcinica
    Imipenem 8 19 ≤1–>16 8 >16 63
    Meropenem 8 18 4–>16 8 >16 33
    Ertapenem 4a 19 4–>16 8 16 21
N. transvalensis complex
    Imipenem 8 18 4–>32 16 >32 22
    Meropenem 8 18 2–16 8 16 83
    Ertapenem 4a 18 2–>16 >16 >16 22
a

Based on the CLSI breakpoint for bacteria (8).