Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Examples of metastatic events, their molecular processes, and potential targeted chemotherapeutics.
| Cellular event | Pathway(s) implicated | Potential personalized treatments |
|---|---|---|
| Migration across BBB | cathepsin S | Inhibitors in development |
| miR-181C | None to date | |
| miR-105 | None to date | |
| Survival in CNS microenvironment | mTOR | Everolimus, temsirolimus |
| CDK | Palbociclib, others in development | |
| VEGF | Bevacizumab | |
| EGFR | Erlotinib | |
| Establishment of radioresistance | Chk1 | Inhibitors in development |
| c-Met | Cabozantinib |
