TABLE 3.

Antifungal susceptibility to echinocandins and liposomal amphotericin B expressed as SMIC₅₀ and SMIC₈₀ of Candida and non-Candida isolates^a

Drug and MIC	SMIC50 (in μg/ml)			SMIC80 (in μg/ml)
	fks mutant	Wild type	Intrinsically resistant	fks mutant	Wild type	Intrinsically resistant
Micafungin
GMb	0.99	0.02	11.28	18.38	0.09	19.03
MIC50	2	≤0.015	≥32	≥32	≤0.015	≥32
MIC90	16	0.125	≥32	≥32	≥32	≥32
Range	≤0.015–16	≤0.015–0.125	0.031–≥32	2–≥32	≤0.015–≥32	0.25–≥32
Anidulafungin
GM	1.74	0.04	15.05	32	0.28	20.09
MIC50	2	0.031	≥32	≥32	0.062	≥32
MIC90	≥32	0.5	≥32	≥32	≥32	≥32
Range	0.062–≥32	≤0.015–0.5	0.062–≥32	≥32–≥32	0.031–≥32	0.125–≥32
Caspofungin
GM	1.51	0.14	6.71	12.13	0.37	32
MIC50	2	0.125	≥32	≥32	0.25	≥32
MIC90	≥32	≥32	≥32	≥32	≥32	≥32
Range	0.062–≥32	≤0.015–≥32	0.125–≥32	0.5–≥32	0.031–≥32	≥32–≥32
Liposomal amphotericin B
GM	0.14	0.29	0.38	2.64	21.11	5.64
MIC50	0.062	0.25	0.25	8	≥32	≥32
MIC90	4	≥32	≥32	≥32	≥32	≥32
Range	0.031–4	0.062–≥32	≤0.015–≥32	0.125–≥32	4–≥32	≤0.015–≥32

^aAntifungal susceptibility to echinocandins and liposomal amphotericin B was expressed as a 50% and 80% reduction in the metabolic activity of the biofilm (SMIC₅₀ and SMIC₈₀, respectively) of the fks mutant Candida isolates, wild-type Candida isolates, and intrinsically echinocandin-resistant non-Candida isolates.

^bGM, geometric mean.