FIG 5.

SpoVG is involved in the control of cell wall metabolism and oxacillin resistance in Staphylococcus aureus strain N315. SpoVG positively regulates the expression of femA, which is involved in the synthesis of pentaglycin cross-links. LytN, a murein hydrolase, is negatively regulated by SpoVG, which is consistent with the hypothesis that SpoVG is a negative regulator of autolysis in S. aureus. Besides, SpoVG acts as a positive regulator for lytSR and, in turn, activates lrgA, leading to the repression of murein hydrolase activity.