TABLE 2.
MIC distributions of tetracycline analogues for Enterobacteriaceae, excluding Proteeae, in relation to carbapenem resistance types
| Drug and characteristic(s) (n) | No. of isolates with characteristic(s) at MIC (μg/ml) ofa: |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤0.06 | 0.13 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | ≥64 | |
| Eravacycline | |||||||||||
| KPC (45) | 3 | 13 | 17 | 9 | 2 | 1 | |||||
| VIM (44) | 16 | 18 | 8 | 2 | |||||||
| IMP (15) | 1 | 4 | 4 | 1 | 5 | ||||||
| NDM (42) | 5 | 16 | 9 | 9 | 2 | 1 | |||||
| OXA-48 (44) | 2 | 18 | 15 | 5 | 2 | 2 | |||||
| Porin loss + ESBL/AmpC (40) | 1 | 13 | 10 | 8 | 5 | 3 | |||||
| Susceptible controls (35) | 2 | 9 | 10 | 11 | 3 | ||||||
| Carbapenemase positive chosen as Tigr (30) | 2 | 4 | 4 | 4 | 6 | 9 | 1 | ||||
| Tigecycline | |||||||||||
| KPC (45) | 8 | 14 | 16 | 4 | 3 | ||||||
| VIM (44) | 6 | 16 | 13 | 8 | 1 | ||||||
| IMP (15) | 1 | 7 | 2 | 5 | |||||||
| NDM (42) | 1 | 6 | 18 | 7 | 9 | 1 | |||||
| OXA-48 (44) | 7 | 22 | 10 | 2 | 2 | 1 | |||||
| Porin loss + ESBL/AmpC (40) | 5 | 11 | 12 | 5 | 5 | 2 | |||||
| Susceptible controls (35) | 1 | 10 | 15 | 9 | |||||||
| Carbapenemase-positive chosen as Tigr (30) | 2 | 4 | 6 | 6 | 9 | 3 | |||||
| Minocycline | |||||||||||
| KPC (45) | 1 | 1 | 14 | 11 | 12 | 3 | 3 | ||||
| VIM (44) | 2 | 8 | 13 | 13 | 4 | 3 | 1 | ||||
| IMP (15) | 1 | 5 | 2 | 1 | 3 | 3 | |||||
| NDM (42) | 1 | 8 | 8 | 8 | 9 | 6 | 2 | ||||
| OXA-48 (44) | 2 | 14 | 13 | 7 | 3 | 3 | 2 | ||||
| Porin loss + ESBL/AmpC (40) | 1 | 6 | 13 | 7 | 5 | 6 | 2 | ||||
| Susceptible controls (35) | 2 | 11 | 14 | 6 | 2 | ||||||
| Carbapenemase positive chosen as Tigr (30) | 1 | 2 | 4 | 6 | 4 | 13 | |||||
| Tetracycline | |||||||||||
| KPC (45) | 5 | 8 | 10 | 2 | 2 | 18b | |||||
| VIM (44) | 1 | 8 | 3 | 1 | 31b | ||||||
| IMP (15) | 1 | 3 | 2 | 2 | 1 | 4 | 2b | ||||
| NDM (42) | 4 | 4 | 7 | 1 | 26b | ||||||
| OXA-48 (44) | 8 | 12 | 6 | 3 | 2 | 13b | |||||
| Porin loss + ESBL/AmpC (40) | 1 | 5 | 9 | 5 | 4 | 16b | |||||
| Susceptible controls (35) | 5 | 13 | 12 | 2 | 2 | 1b | |||||
| Carbapenemase positive chosen as Tigr (30) | 1 | 2 | 2 | 3 | 5 | 17b | |||||
a
MIC50s are underlined, and MIC90s are in boldface; in some cases, these values coincide.
b
The MIC is greater than or equal to the indicated value.