FIG 2.

In vivo dose effects of ACT-387042 (A) and ACT-292706 (B) against select S. pneumoniae (blue lines) and S. aureus (red lines) isolates in a neutropenic mouse thigh model. Each symbol represents the mean and standard deviation from three mice (six thighs). Five or six total drug dose levels were fractionated into an every-3-hour regimen. The burden of organisms was measured at the start and end of therapy. The study period was 24 h. The horizontal line at zero represents the burden of organisms in the thighs of mice at the start of therapy. Data points below the line represent killing, and points above the line represent growth.