TABLE 2.

Pharmacodynamic targets for ACT-387042 and ACT-292706 against select S. pneumoniae and S. aureus isolates^a

Drug and organism	Static dose (mg/kg/24 h)	24-h static-dose AUC/MIC ratio (total drug)	24-h static-dose AUC/MIC ratio (free drug)	1-log-kill dose (mg/kg/q24h)	24-h 1-log-kill AUC/MIC ratio (total drug)	24-h 1-log-kill AUC/MIC ratio (free drug)
ACT-387042
SA 29213	60.9	209.1	25.1	104.9	343.6	41.2
SA 33591	55	191.1	22.9	208.4	669.2	80.3
SA 307109	42.4	153.4	18.4	48.8	172.4	20.7
SA WIS-1	146.2	943.5	113.2	361.3	2,349.8	282
SA 25923	89.3	295.5	35.4	194.9	625.9	75.1
Mean	78.8	358.5	43*	183.7	832.2	99.9
Median	60.9	209.1	25.1	194.9	625.9	75.1
SD	41.4	331.2	39.7	119.1	872.7	104.7
ACT-387042
SPN 1396	25.7	49.5	5.9	81.8	129.4	15.5
SPN 1293	48.8	82.8	9.9	112.1	175.6	21.1
SPN MNO-418	27.9	109.7	13.2	49.9	175.6	21.1
SPN 10813	53.2	89.2	10.7	128.3	199.6	24
Mean	38.9	82.8	9.9*	93	170.1	20.4
Median	38.35	86	10.3	96.95	175.6	21.1
SD	14.1	25	3	34.6	29.4	3.5
ACT-292706
SA 29213	189	782	46.9	NA
SA 33591	186	1,540	92.4	NA
SA 307109	158	1,307	78.4	216	2,267	136
SA WIS-1	168	1,390	83.4	254	2,919	175
SA 25923	86	695	41.7	156	1,491	89
Mean	157	1,143	68.6**	209	2,226	133
Median	168	1,307	78.4	216	2,267	136
SD	42	380	22.8	49	715	43
ACT-292706
SPN 49619	136	563	33.8	319	2,019	121
SPN 1396	161	318	19.1	NA
SPN 1293	NA			NA
SPN MNO418	76	640	38.4	205	2,070	124
SPN 10813	72	136	8.2	141	315	19
Mean	111	414	24.9**	222	1,468	88
Median	106	440.5	26.5	205	2,019	121
SD	44	231	13.8	90	999	60

^a*, P = 0.016; **, P = 0.012; NA, not achieved; q24h, every 24 h.