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TDF-NPs in TMS gel prevention curve. Control humanized mice (n = 8) received blank TMS gel, and 100% of them were infected within 14 days p.i. All humanized mice receiving 0.1% TDF-NPs and challenged 4 h later (n = 4) or receiving 0.5% TDF NPs and challenged 24 h later (n = 6) were protected from HIV-1 infection (P = 0.005).
