TABLE 4.

Top 25 posaconazole-interacting drugs by frequency of DDIs^a

Interacting medication	Severity of DDI	Frequency of DDIs	Rate of DDIs (%)
Ondansetron	Contraindicated	212	54.9
Lorazepam	Moderate	165	42.7
Promethazine	Major	120	31.1
Ciprofloxacin	Major	113	29.3
Prochlorperazine	Major	105	27.2
Esomeprazole	Major	83	21.5
Fentanyl	Major	80	20.7
Pantoprazole	Moderate	80	20.7
Levofloxacin	Major	67	17.4
Midazolam	Major	67	17.4
Lansoprazole	Moderate	56	14.5
Tacrolimus	Contraindicated	49	12.7
Amlodipine	Moderate	48	12.4
Fluconazole	Major	46	11.9
Sirolimus	Contraindicated	28	7.3
Alprazolam	Major	24	6.2
Metoclopramide	Moderate	24	6.2
Simvastatin	Contraindicated	20	5.2
Azithromycin	Major	18	4.7
Tamsulosin	Major	18	4.7
Escitalopram	Contraindicated	16	4.1
Haloperidol	Contraindicated	16	4.1
Moxifloxacin	Major	15	3.9
Warfarin	Major	13	3.4
Cyclosporine	Major	12	3.1

^aData are for 386 posaconazole-treated patients with DDIs.