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Model of CrrC-mediated colistin resistance in K. pneumoniae. Two-component systems (CrrAB, PmrAB, and PhoPQ) are regulated by a negative regulator (MgrB) and connectors (CrrC and PmrD). A mutation(s) or interruption(s) in these components could abnormally regulate the downstream locus and result in increasing LPS modification-associated loci (pmrHFIJKLM operon and pmrC).
