TABLE 2.
Blood pharmacokinetic parameters in BALB/c mice after single oral gavage administration of compound 1
| Value | Actual dose (mg/kg of body weight) | Cmax (ng/ml) | Cmax/Da (kg · ng/ml/mg) | AUCall (h · ng/ml) | AUC∞ observed (h · ng/ml) | AUC∞/D observedb (h · kg · ng/ml/mg) |
|---|---|---|---|---|---|---|
| By animal ID | ||||||
| 1 | 50 | 227.0 | 4.5 | 401.0 | 438.1 | 8.8 |
| 2 | 50 | 154.0 | 3.1 | 339.7 | 358.4 | 7.2 |
| 3 | 50 | 95.9 | 1.9 | 227.6 | 238.8 | 4.8 |
| Overall | ||||||
| Average | 159.0 | 3.2 | 322.8 | 345.1 | 6.9 | |
| SDc | 65.7 | 1.3 | 87.9 | 100.3 | 2.0 |
a
Cmax/D, dose-normalized value of Cmax (Cmax/experimental dose).
b
AUC∞/D, dose-normalized value of AUC (AUC/experimental dose).
c
SD, standard deviation.