TABLE 2.
Pharmacokinetic parameters of posaconazole in CF and non-CF group
| Parameter | Median (range) |
Pa | |
|---|---|---|---|
| CF cohort (n = 7) | Non-CF cohort (n = 12) | ||
| Tmax (h) | 4.4 (0–7.8) | 4 (0–11.8) | 0.4 |
| Css,max (μg/ml) | 0.311 (0.021–0.968) | 0.699 (0.227–2.983) | NA |
| Css,min (μg/ml) | 0.189 (0–0.619) | 0.474 (0.115–2.094) | NA |
| Css,av (μg/ml) | 0.233 (0.01–0.772) | 0.594 (0.154–2.455) | 0.03 |
| AUC0–24/daily dose (h·μg/ml) | 0.007 (0.0003–0.019) | 0.02 (0.005–0.074) | 0.02 |
| Apparent oral clearance (liters/h) | 143.16 (32.26–3278.69) | 51.83 (13.58–216.33) | 0.13 |
| Wt-normalized apparent oral clearance (liters/h/kg) | 2.51 (0.76–48.22) | 0.74 (0.25–2.66) | 0.005 |
a
NA, not applicable. Statistic analyses are not applicable to Css,max and Css,min values because the dosing intervals were variable among enrolled patients.