Figure 2.

Simulated and observed naloxegol peak plasma concentration (C_max) and area under the curve (AUC) ratios when coadministered with weak, moderate, and strong inhibitors and moderate and strong inducers of cytochrome P450 (CYP)3A, with 90% confidence intervals. Dashed lines represent the (80%, 125%) interval. Verification and prediction are both model‐predicted interaction results, but indicate cases in which the actual clinical drug‐drug interaction (DDI) studies were conducted (verification) or were not (prediction).