Table 2.

List of model parameters (k_on and K_D are the only parameters that were fixed based on in vitro measurements and the rest were estimated in the model)

Name	Description	Value (Units)
CL	Non‐specific elimination clearance of antibody	0.0039 (L/day/kg)
CLd	Distribution clearance of antibody	0.0188 (L/day/kg)
kon	Association rate of antibody to TfR (fixed)	17.9 (1/nM/day)
KD	Dissociation constant for antibody binding to TfR (fixed)	See Table 3 (ug/ml)
Vi	Volume of central/peripheral compartment	0.0322/0.0289 (L/kg)
$Sy{n}_{C/b}^R$	Rate of TfR synthesis in central/brain compartment	886/341 (nM/day)
$De{g}_{C/b}^R$	Rate of TfR degradation in central/brain compartment	2‐1 / 7 (1/day)
$De{g}_C^{AbR}$	Rate of antibody‐TfR complex degradation in central compartment	0.305 (1/day)
kint	Rate of antibody‐TfR complex internalization into brain	5.72 (1/day)
kbuns	Rate of non‐specific uptake of antibody into the brain	0.016 (1/day)
ktrans	Rate of antibody transcytosis into brain cortex	200 (1/day)
$De{g}_{Cortex}^C$	Rate of antibody clearance from brain cortex	291 (1/day)
SynA β	Rate of Aβ synthesis in the brain cortex	100 (nM/day)
$De{g}_{Cortex}^{A\beta }$	Rate of Aβ degradation in brain cortex	2.5 (1/day)
$V_m^{BACE}$	Maximum effect of BACE inhibition by antibody on AP production (fixed)	0.75 (dimensionless)
$K_m^{BACE}$	Antibody concentration at which its effect is half the maximum effect	6.67 (nM)

TfR, transferrin receptor.