Table 1.
Demographic characteristics, cognitive performance, and concentrations of cerebrospinal fluid biomarkers (Aβ1–42, T-tau, and P-tau) according to baseline diagnosis
| Diagnosis |
P | ||||
|---|---|---|---|---|---|
| Healthy controls | MCI | AD | Non-AD | ||
| Gender (%W) | 70% | 77% | 58% | 57% | .14 |
| Age | 69.68 (8.66) | 70.22 (10.23) | 74.23 (6.61) | 68.38 (9.38) | .04 |
| Years of education | 12.85 (5.81) | 10.59 (6.55) | 7.02 (4.99) | 10.25 (7.43) | .07 |
| MMSE | 29.54 (5.22) | 29.35 (9.96) | 23.81 (11.27) | 27.09 (9.40) | .02 |
| CAMCOG | 92.54 (13.63) | 85.40 (21.30) | 67.43 (21.92) | 78.08 (25.27) | <.001 |
| Aβ1-42 | 503.99 (156.67) | 410.91 (149.98) | 328.76 (110.54) | 474.11 (185.88) | <.001 |
| Total tau | 86.03 (47.47) | 88.38 (55.75) | 145.69 (80.22) | 104.59 (85.04) | <.001 |
| Phosphorylated tau | 41.59 (21.81) | 45.92 (27.11) | 66.72 (35.82) | 38.97 (26.41) | <.001 |
| Aβ1-42/P-tau | 14.38 (6.46) | 12.09 (7.34) | 7.39 (7.39) | 15.82 (8.43) | <.001 |
| Aβ1-42/T-tau | 7.12 (3.48) | 6.40 (3.82) | 3.45 (4.01) | 6.76 (4.73) | <.001 |
Abbreviations: Aβ1–42, amyloid-beta peptide; T-tau, total tau; P-tau, 181Thr-phosphorylated-tau; MCI, mild cognitive impairment; AD, Alzheimer's disease; Non-AD, cognitive impairment or dementia due to other etiologies; MMSE, mini-mental state examination; CAMCOG, cognitive test Cambridge.
NOTE. Biomarker concentrations are given in pg/mL. Values are presented as means and standard-deviations.