Table 1.
Baseline characteristics∗ of AD cases and controls
| Characteristics | AD cases (n = 197) | Controls (n = 198) | P value |
|---|---|---|---|
| Age at visit (y) | 77.41 (8.29) | 70.42 (8.89) | <.001 |
| Sex (% male) | 34.52 | 31.82 | .75 |
| BMI | 25.68 (5.06) | 27.43 (4.81) | <.001 |
| MMSE | 19.18 (6.22) | 29.42 (0.88) | <.001 |
| Lp-PLA2 (ug/L) | 297.0 (71.6) | 281.11 (65.7) | .02 |
| Median (IQR) | 300.08 (83.65) | 276.20 (94.40) | .02 |
| Homocysteine (u/M) | 16.21 (9.01) | 13.3 (5.03) | <.001 |
| Median (IQR) | 14.30 (8.75) | 12.20 (6.30) | <.001 |
| CRP (ug/mL) | 3.23 (4.87) | 3.68 (4.14) | .32 |
| Cholesterol (mg/L) | 210.12 (50.11) | 209.35 (62.04) | .40 |
| CVDE† | 48.22 | 46.46 | .73 |
Abbreviations: AD, Alzheimer's disease; BMI, body mass index (calculated as weight in kilograms divided by the square of height in meters); MMSE, mini-mental state examination; Lp-PLA2, lipoprotein-associated phospholipase A2; IQR, interquartile range; CRP, C-reactive protein; CVDE, cardiovascular disease equivalent; CHD, coronary heart disease.
∗
Unadjusted mean values (standard deviations) or proportions.
†
CVDE calculated according to the Adult Treatment Panel III guidelines [34] (history of myocardial infarction, stent placement, congestive heart failure, diabetes, or increased risk of CHD with any two of hypertension, hyperlipidemia, or current cigarette smoking).