Table 4.
Adjusted∗ odds ratio of Alzheimer's disease in relation to CVDE and Lp-PLA2
| Variables and interactions | Odds ratio | 95% CI | P value |
|---|---|---|---|
| Lp-PLA2† × CVDE | — | — | .02 |
| CVDE | — | — | .06 |
| CVDE = 1, Lp-PLA2† | 1.72 | 0.89–3.34 | — |
| CVDE = 0, Lp-PLA2+ | 0.53 | 0.27–1.02 | — |
| Lp-PLA2 | — | — | .79 |
| Lp-PLA2†, CVDE = 1 | 3.56 | 1.08–6.99 | — |
| Lp-PLA2+, CVDE = 0 | 1.08 | 0.59–2.02 | — |
| Age (y) | 1.10 | 1.07–1.113 | <.001 |
| Sex (M vs. F) | 1.30 | 0.80–2.09 | .29 |
| BMI | 0.98 | 0.93–1.03 | .40 |
Abbreviations: CVDE, cardiovascular disease equivalent [34]; Lp-PLA2, lipoprotein-associated phospholipase 2; CI, confidence interval; Lp-PLA2 × CVDE, interaction term; CVDE = 1, CVDE present; CVDE = 0, CVDE absent; M, male; F, female; BMI, body mass index.
∗
Adjusted for age, sex, and body mass index.
†
Lp-PLA2 above median, +Lp-PLA2 below median.