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. 2016 May 25;6:26442. doi: 10.1038/srep26442

Figure 1. ERRγ changes myofiber type in db/db mice.

Figure 1

Changes in myofiber type were measured in 6 month-old male non-fasted db/+ (hatched bars), db/db (open bars) and db/db-ERRγ (black bars) mice. (A) Myosin heavy chain (MyHC) gene expression in gastrocnemius muscles (N = 6–7). (B–D) Immunohistological myofiber type staining in Tibialis Anterior (TA) muscles for MyHC IIA (green), IIB (red), and IIX (unstained). (B) Representative images of the medial (left) and outer (right) TA cross-sections. (C,D) Percentage of positive fibers in the medial (C) and outer TA (D) (N = 5–6). *Indicates comparison to db/+ mice; †indicates db/db compared with db/db-ERRγ mice. (*/†p < 0.05, **/††p < 0.01, ***/†††p < 0.001, One-way ANOVA with Tukey’s post-hoc test).