Figure 5. ERRγ does not increase energy expenditure in db/db mice.

(A) Weekly measure of total body weight of male mice (N = 25–23). (B) Fat mass in 5 months-old male mice (N = 7–9). (C–E) Energy expenditure (C), ambulatory activity (D) and food intake (E) in 5 month-old male mice (N = 5–7). In (A,C,D): db/+ (▴), db/db (○) and db/db-ERRγ (▪). In (B,E): db/+ (hatched bar), db/db (open bar) and db/db-ERRγ (black bar). (***p < 0.001, One-way ANOVA with Tukey’s post-test).