Table 3. Adjusted odds ratio (AOR) and 95% confidence interval (CI) of clinical status and SERPINB5 rs2289520 genotypic frequencies in 302 HCC patients with tobacco consumption.
| Variables | Genotypic frequencies | |||
|---|---|---|---|---|
| GG (N = 169) | GC + CC (N = 133) | OR (95% CI) | P value† | |
| Clinical Stage | ||||
| Stage I/II | 114 (67.5%) | 84 (63.2%) | 1.00 | P = 0.435 |
| Stage III/IV | 55 (32.5%) | 49 (36.8%) | 1.209 (0.750–1.948) | |
| Tumor size | ||||
| ≦T2 | 118 (69.8%) | 84 (63.2%) | 1.00 | P = 0.222 |
| >T2 | 51 (30.2%) | 49 (36.8%) | 1.350 (0.834–2.185) | |
| Lymph node metastasis | ||||
| No | 162 (95.9%) | 131 (98.5%) | 1.00 | P = 0.181 |
| Yes | 7 (4.1%) | 2 (1.5%) | 0.353 (0.072–1.730) | |
| Distant metastasis | ||||
| No | 156 (92.3%) | 129 (97.0%) | 1.00 | P = 0.080 |
| Yes | 13 (7.7%) | 4 (3.0%) | 0.372 (0.118–1.169) | |
| Vascular invasion | ||||
| No | 141 (83.4%) | 115 (86.5%) | 1.00 | P = 0.466 |
| Yes | 28 (16.6%) | 18 (13.5%) | 0.788 (0.415–1.497) | |
| Child–Pugh grade† | ||||
| A | 122 (72.2%) | 109 (82.0%) | 1.00 | P = 0.047* |
| B or C | 47 (27.8%) | 24 (18.0%) | 0.527 (0.328–0.996) | |
| HBsAg | ||||
| Negative | 107 (63.3%) | 70 (52.6%) | 1.00 | P = 0.061 |
| Positive | 62 (36.7%) | 63 (47.4%) | 1.553 (0.978–2.466) | |
| Anti–HCV | ||||
| Negative | 79 (46.7%) | 77 (57.9%) | 1.00 | P = 0.054 |
| Positive | 90 (53.3%) | 56 (42.1%) | 0.638 (0.404–1.009) | |
| Liver cirrhosis | ||||
| Negative | 30 (17.8%) | 35 (26.3%) | 1.00 | P = 0.072 |
| Positive | 139 (82.2%) | 98 (73.7%) | 0.604 (0.348–1.049) | |
The ORs with analyzed by their 95% CIs were estimated by logistic regression models. >T2 indicated the multiple tumor more than 5 cm or tumor involving a major branch of the portal or hepatic vein(s). *P value < 0.05 as statistically significant.
†Child-Pugh grades indicate the severity of cirrhosis: A = 5–6 points, B = 7–9 points and C = 10–15 points.