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. 2016 May 25;6:26734. doi: 10.1038/srep26734

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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A simplified representation of dysplastic proliferation arising at the basement membrane in the oral cavity (a–c) showing normal cells (gray with nuclei), dysplastic cells (light gray with nuclei), basement membrane (dark gray), and the stroma (gray). The associated dysplasia-mimicking phantom models (d–f) simulate this progression. Two SDSs (374 and 730 μm) deliver and collect broadband light at different depths (detected photons shown here as blue and red crescents, respectively). Each of thin phantom layers was 150 μm thick for a total phantom thickness of 300 μm to simulate the thickness of oral epithelium.