Fig. 1.

Coronal views of the brain showing regions of statistically significant anatomical variation across XX, XY and XXY groups. Brain images show a thresholded F-statistic map after (after False Discovery Rate correction for multiple comparisons) for the omnibus effect of “Group” on brain volume (color scale as per F-statistic bar). Two patterns of significant group effect are detected. Both XY and XXY mice show volume increases relative to XX females within the bed nucleus of the stria terminalis (BNST) and medial amygdala. Conversely, XY and XXY mice both show volume decreases relative to XX females within the somatosensory and retrosplenial cortices (CTXss and CTXrs respectively), and the ventral group nuclei of the dorsal thalamus