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Patient dispositions. DLT, dose-limiting toxicity; MTD, maximum-tolerated dose. (*) Two DLTs: Grade 3 palmar-plantar erythrodysaesthesia syndrome and grade 4 rash/neutropenic fever. (†) Two events of grade 3 rash and one event of grade 2 erythema multiforme. (‡) Three DLTs: grade 3 hyperglycemia/rash, grade 3 rash, and grade 5 toxic epidermal necrolysis. (§) Grade 4 rash with grade 3 pruritus. (‖) Grade 5 renal failure.
