Table A2.
Association of the Risk of Early MM Progression–Related Death With the Three Prognostic Variables
| Variable | IFM 2005-01 (n = 387) | GIMEMA/PETHEMA/HOVON-GMMG (n = 1,139) | GIMEMA (n = 390) | PETHEMA (n = 353) | HOVON-GMMG (n = 396) |
|---|---|---|---|---|---|
| ISS3 | |||||
| Coefficient | 0.9214 | 0.9850 | 0.8865 | 1.2765 | 0.8185 |
| SE | 0.3862 | 0.2408 | 0.5366 | 0.4144 | 0.3653 |
| P | .020 | < .001 | .120 | .003 | .028 |
| LDH > normal | |||||
| Coefficient | 1.0173 | 0.8173 | 0.0017 | 0.9277 | 0.8492 |
| SE | 0.3929 | 0.2666 | 1.3441 | 0.4503 | 0.3940 |
| P | .012 | .003 | .99 | .048 | .033 |
| del(17p) or t(4;14) | |||||
| Coefficient | 1.5132 | 1.0522 | 1.3441 | 1.5279 | 0.7483 |
| SE | 0.4073 | 0.2363 | 0.4924 | 0.4260 | 0.3650 |
| P | < .001 | < .001 | .007 | < .001 | .044 |
Abbreviations: GIMEMA, Gruppo Italiano Malattie Ematologiche dell' Adulto; GMMG, German-Speaking Myeloma Multicenter Group; HOVON, Hemato-Oncologie voor Volwassenen Nederland; IFM, Intergroupe Francophone du Myélome; ISS3, International Staging System 3; LDH, lactate dehydrogenase; MM, multiple myeloma; PETHEMA, Programa para el Estudio de la Terapéutica en Hemopatía Maligna.