Table 1.
Correlation Between Histologic Prediction and Genomic Data in Multiple Lung Carcinomas of Similar Histologic Subtype
| Sample No. | Tumor 1 |
Tumor 2 |
Histologic Prediction | Genomic Prediction | ||
|---|---|---|---|---|---|---|
| Type | Location | Type | Location | |||
| LU26 | RLL | LUL | Unrelated | |||
| R1 | AD pred cribriform (C, 80%; A, 10%; S, 10%) | AD pred acinar (A, 50%; L, 40%; P, 10%) | Independent primary tumors | |||
| R2 | AD pred solid (S, 50%; C, 50%) | AD pred papillary (P, 40%; A, 30%; L, 10%; C, 10%; S, 10%) | Independent primary tumors | |||
| LU28 | RML | LUL | Unrelated | |||
| R1 | AD pred solid (S, 90%; A, 10%) | AD pred solid (S, 90%; A, 10% + giant cells) | Independent primary tumors | |||
| R2 | AD pred solid (S, 80%; A, 10%; MP, 10%) | AD pred solid (S, 100% with signet ring or large-cell features) | Favor independent primary tumors | |||
| LU32 | RLL | LUL | Unrelated | |||
| R1 | AD pred acinar (A, 70%; L, 30%) | MIA | Independent primary tumors | |||
| R2 | AD pred acinar (A, 50%; P, 50%) | AD pred lepidic (L, 70%; A, 30%) | Independent primary tumors | |||
| LU43 | RLL | RLL | Unrelated | |||
| R1 | AD mucinous | AD pred acinar (A, 70%; C, 20%; P, 10%) | Independent primary tumors | |||
| R2 | AD mucinous | AD pred acinar (A, 70%; P, 30%) | Favor independent primary tumors | |||
| LU45 | LUL | RUL | Unrelated | |||
| R1 | AD pred solid (S, 45% A 35% L 20%) | AD pred acinar (A, 70%; L, 20%; S, 10%) | Indeterminate: independent primary tumors | |||
| R2 | AD pred acinar (A, 50%; S, 20%; L, 20%; C, 10%) | AD pred acinar (A, 40%; L, 30%; S, 20%; P, 10%) | Favor metastasis | |||
| LU27 | RLL | RML | Related | |||
| R1 | AD mucinous | AD mucinous | Metastasis | |||
| R2 | AD mucinous | AD mucinous | Metastasis | |||
| LU29 | RUL | Lingula | Related | |||
| R1 | SQCC G3 | SQCC G3 | Metastasis | |||
| R2 | SQCC G3 | SQCC G3 | Favor metastasis | |||
| LU30 | RML | LLL | Related | |||
| R1 | AD mucinous | AD mucinous | Metastasis | |||
| R2 | AD mucinous | AD mucinous | Favor metastasis | |||
| LU40 | RML/RLL | LLL | Related | |||
| R1 | SQCC G3 | SQCC G3 | Favor metastasis | |||
| R2 | SQCC G2-3 | SQCC G2-3 | Metastasis | |||
| LU41 | LUL | RUL | Unrelated | |||
| R1 | SQCC G2 | SQCC G2 with CIS | Favor metastasis | |||
| R2 | SQCC G2 | SQCC G1-2 with CIS | Metastasis | |||
| LU44 | RLL | LUL | Unrelated | |||
| R1 | AD pred solid (S, 75%; C, 20%; A, 5%) | AD pred solid (S, 50%; C, 25%; A, 25%) | Indeterminate metastasis | |||
| R2 | AD pred solid (S, 90%; A, 10%) | AD pred solid (S, 80%; A, 20%) | Independent primary tumors | |||
Abbreviations: A, acinar; AD, adenocarcinoma; C, cribriform; G, grade; L, lepidic; LLL, left lower lung; LUL, left upper lung; MIA, minimally invasive adenocarcinoma; P, papillary; pred, predominant; RLL, right lower lung; RML, right middle lung; RUL, right upper lung; S, solid; SQCC, squamous cell carcinoma.