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Bioenergetic pathways underlying CSC metabolism. In more differentiated cancer cells, the glycolytic phenotype might predominate over oxidative phosphorylation (OXPHOS). CSCs instead might rely more on an oxidative metabolism for their energy production. CSCs also appear to be metabolically plastic: when OXPHOS is blocked they can eventually develop resistance by acquiring an intermediate glycolytic/oxidative phenotype. ROS reactive oxygen species, TCA tricarboxylic acid
