Table 4.
Estimated mean difference of cytokines serum levels between CC cases and controls stratified by genotypes
| Diagnosis | βa coefficient (95 % CI) | ||||
|---|---|---|---|---|---|
| Polymorphism | Total without stratification | Ancestral allele homozygote | Heterozygote | Minor allele homozygote | |
| IL-4 -590C > T (rs2243250) | CC | CT | TT | ||
| NCL | - | - | - | - | |
| CC | 1.0 (0.696,1.307) | 0.61 (0.269,0.970) | 1.22 (0.713,1.736) | 0.87 (0.214,1.539) | |
| IL-6 -573G > C (rs1800796) | GG | GC | CC | ||
| NCL | - | - | - | - | |
| CC | 2.63 (2.063,3.199) | 3.12 (2.261,3.994) | 2.39 (1.567,3.230) | 2.20 (0.367,4.042) | |
| IL-10 -592C > A (rs1800872) | CC | CA | AA | ||
| NCL | - | - | - | - | |
| CC | 2.55 (2.255,2.859) | 2.27 (1.805,2.737) | 2.55 (2.063,3.04) | 2.62 (1.911,3.333) | |
| IL-10 -819C > T (rs1800871) | CC | CT | TT | ||
| NCL | - | - | - | - | |
| CC | 2.55 (2.255,2.859) | 2.24 (1.760,2.722) | 2.45 (1.980,2.927) | 2.83 (2.111,3.555) | |
| IL-10 -1082A > G (rs1800896) | AA | AG | GG | ||
| NCL | - | - | - | - | |
| CC | 2.55 (2.255,2.859) | 2.48 (2.078,2.898) | 2.77 (2.261,3.291) | 1.13 (0.508,1.758) | |
| IFN-γ -1615C > T (rs2069705) | CC | CT | TT | ||
| NCL | - | - | - | - | |
| CC | −2.58 (−3.286,-1.891) | −2.80 (−3.687,-1.927) | −2.61 (−3.929,-1-291) | −1.7 (−6.097,2.685) | |
| TNF-α -308G > A (rs 1800629) | GG | GA | AA | ||
| NCL | - | - | - | - | |
| CC | −0.94 (−1.026,-0.860) | −0.91 (−1.003,-0.816) | −1.08 (−1.30,-0.876) | −1.33 (−1.85,-0.813) | |
| TGFB1 -509C > T (rs1800469) | CC | CT | TT | ||
| NCL | - | - | - | - | |
| CC | 13.4 (11.52,15.47) | 19.5 (15.85,23.17) | 11.2 (8.686,13.71) | 8.7 (2.54,14.98) | |
Bold text denotes significant p values (p < 0.05)
aAdjusted by age, CC history and smoking history
Levels of serum cytokines are expressed in pg/ml except TGFB1 (ng/ml)