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Loess curve of Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) physical function values in the Multicenter Osteoarthritis Study at the last visit before total knee replacement (TKR). The time of the last visit varied from 0 to 60 months prior to TKR surgery, as shown on the X-axis. The fitted line was used to calculate pre-TKR values at the time point 0 (32.1 units + deviation from line).
