Table 1.
Enzymes involved in polyP metabolism studied in eukaryotes.
| Enzyme abbreviation | Enzyme name | Protein Function | Organism | NCBI Reference number | Ref. |
|---|---|---|---|---|---|
| DdPPK1 | PolyP kinase 1 | PolyP synthesis | D. discoideum | AAD53165.1 | 38 |
| DdPPK2 | PolyP kinase 2 | Reversible polyP synthesis | D. discoideum | XP_636500.1, XP_645275.1, XP_636191.1 | 39 |
| Vtc1p | Vacuolar Transporter Chaperone 1 | PolyP synthesis (subunit of VTC complex) | S. cerevisiae | NP_010995.1 | 41, 42 |
| Vtc2p | Vacuolar Transporter Chaperone 2 | PolyP synthesis (subunit of VTC complex) | S. cerevisiae | NP_116651.1 | 41, 42 |
| Vtc3p | Vacuolar Transporter Chaperone 3 | PolyP synthesis (subunit of VTC complex) | S. cerevisiae | NP_015306.1 | 41, 42 |
| Vtc4p | Vacuolar Transporter Chaperone 4 | PolyP synthesis (catalytic subunit of VTC complex) | S. cerevisiae | NP_012522.2 | 40–42 |
| CrVtc1 | Vacuolar Transporter Chaperone 1 | PolyP synthesis (subunit of VTC complex) | C. reinhardtii | XP_001690865.1 | 47 |
| CmVtc1 | Vacuolar Transporter Chaperone 1 | PolyP synthesis (subunit of VTC complex) | C. merolae | XP_005537755.1 | 28 |
| TbVtc1 | Vacuolar Transporter Chaperone 1 | PolyP synthesis (subunit of VTC complex) | T. brucei | XP_846013.1 | 26, 45 |
| TbVtc4 | Vacuolar Transporter Chaperone 4 | PolyP synthesis (catalytic subunit of VTC complex) | T. brucei | XP_829284.1 | 26, 43, 44 |
| TcVtc4 | Vacuolar Transporter Chaperone 4 | PolyP synthesis (catalytic subunit of VTC complex) | T. cruzi | XP_821342.1 | 44 |
| TgVtc2 | Vacuolar Transporter Chaperone 2 | PolyP synthesis (subunit of VTC complex) | T. gondii | XP_002372055.1 | 46 |
| ScPPX1 | Exopoly phosphatase 1 | PolyP hydrolysis | S. cerevisiae | AAA65933.1 | 58 |
| ScPPN1 | Endopoly phosphatase 1 | PolyP hydrolysis | S. cerevisiae | NP_010740.3 | 59 |
| TcPPX | Exopoly phosphatase | PolyP hydrolysis | T. cruzi | AAQ11880.1 | 60 |
| LmPPX | Exopoly phosphatase | PolyP hydrolysis | L. major | CBZ11834.1 | 61 |
| TbPPX | Exopoly phosphatase | PolyP hydrolysis | T. brucei | AAP74699.1 | 62 |
| TbVSP | Vacuolar Soluble Pyrophosphate | PolyP and PPi hydrolysis | T. brucei | AAP74702.1 | 48 |
| LaVSP | Vacuolar Soluble Pyrophosphate | PolyP and PPi hydrolysis | L. amazonensis | AAP74700.1 | 49 |
| TcVSP | Vacuolar Soluble Pyrophosphate | PolyP and PPi hydrolysis | T. cruzi | XP_807207.1 | 50 |